Telfair Square is one of the 22 squares of Savannah, Georgia, United States. It is located in the second row of the city's five rows of squares, on Barnard Street and West President Street, and was laid out in 1733 as one of the first four squares. It is south of Ellis Square, west of Wright Square and north of Orleans Square. Liberty Square formerly stood to its west but was later paved over. The oldest building on the square is Telfair Academy, at 121 Barnard Street, which dates to 1818–1820.

Originally named St. James Square, in honor of a green space in London, and marked one of the most fashionable neighborhoods in early Savannah, it was renamed in 1883 to honor the Telfair family. It is the only square honoring a family rather than an individual or an event. The Telfairs included former governor of Georgia Edward Telfair, Congressman Thomas Telfair (Edward Telfair's son), and his daughter Mary Telfair (1791–1875), benefactor of Savannah's Telfair Museum of Art. The square also contains tributes to the Girl Scouts of the USA, founded by Savannahian Juliette Gordon Low, and to the chambered nautilus.