Oglethorpe Square is one of the 22 squares of Savannah, Georgia, United States. It is located in the second row of the city's five rows of squares, on Abercorn Street and East President Street, and was laid out in 1742. It is south of Reynolds Square, west of Columbia Square, north of Colonial Park Cemetery and east of Wright Square. The oldest building on the square is the Owens–Thomas House, at 124 Abercorn Street, which dates 1819.

Upper New Square, as it was originally known, was laid out in 1742 and was later renamed in honor of Georgia founder General James Oglethorpe, although his statue is located in Chippewa Square, to the southwest.

The home of Georgia's first Royal Governor, John Reynolds, was located on the southeastern trust lot (now a parking lot of The Presidents' Quarters Inn) overlooking the square. Reynolds arrived in Savannah on October 29, 1754.

The residences of the Royal Surveyors of Georgia and South Carolina were located on the northeastern trust lots, the site of today's Owens–Thomas House. The Presidents' Quarters Inn, a 16-room historic bed and breakfast, is located in the southeastern trust lot.